Validating rnai targets

Our si RNA screening efforts have initially focused on SM-induced inflammation in cutaneous injury since chronic inflammation after exposure appears to play a role in progressive clinical pathology, and intervention may improve clinical outcome.

Also, targets that mitigate cellular injury should reduce the inflammatory response.

New validated drug targets are required to allow development of new classes of antifilarial drugs.

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Human tissue microarray analysis also reveals that high PHB1 tumor expression is associated with poorer overall survival in patients with NSCLC, further suggesting PHB1 as a therapeutic target.

We expect this long-circulating RNAi NP platform to be of high interest for validating potential cancer targets in vivo and for the development of new cancer therapies.

The new generation lipid-polymer hybrid NPs are small and uniform, and can efficiently encapsulate si RNA and control its sustained release.TY - JOURT1 - Long-circulating si RNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment AU - Zhu, Xi AU - Xu, Yingjie AU - Solis, Luisa M. AU - Shi, Jinjun PY - 2015/6/23Y1 - 2015/6/23N2 - RNA interference (RNAi) represents a promising strategy for identification and validation of putative therapeutic targets and for treatment of a myriad of important human diseases including cancer.AU - Tao, Wei AU - Wang, Liangzhe AU - Behrens, Carmen AU - Xu, Xiaoyang AU - Zhao, Lili AU - Liu, Danny AU - Wu, Jun AU - Zhang, Ning AU - Wistuba, Ignacio I. However, the effective systemic in vivo delivery of small interfering RNA (si RNA) to tumors remains a formidable challenge.Gene silencing by RNA interference (RNAi) has become a standard method for the characterization of gene function in mammalian cells.Short hairpin (sh) RNAs expressed from stably integrated vectors mediate gene knockdown both in cultured cells and in mice, presenting a fast alternative to gene knockout approaches.The matrix metalloproteinases (MMPs) mediate homeostasis of the extracellular environment.

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